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. 2014 Feb 14;3(1):92–111. doi: 10.3390/cells3010092

Figure 6.

Figure 6

Expression of i21VEGFR-1 is positively regulated by the Notch pathway and negatively regulated by the micro RNA family miR-200. Addition of retinoic acid to the culture medium of MDA-MB-231 breast cancer cells inhibits the expression of the protein i21VEGFR-1. The effect of retinoic acid on the expression of the intracellular truncated isoform of VEGFR-1 is mediated by downregulation of Notch-3 expression. Moreover, retinoic acid increases the expression of the miR-200 family of micro RNAs in MDA-MB-231 breast cancer cells. The expression of the truncated intracellular protein i21VEGFR-1 decreases when the Notch signaling pathway is interfered withγ-secretase inhibitors.