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. 2013 Nov 11;6(Suppl 3):S9. doi: 10.1186/1755-8794-6-S3-S9

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Copyright © 2013 Wang et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Model-based CART analysis based on the biomarker AFP conditional on the tree analysis using GP73, AAT, Kininogen and age, after controlling for site, for the stratified male-only subset. Once again, age alone plays a significant role in the incidence of HCC (p < 0.001). The node pair (1,7) represents the sub-group of 42 men aged >61 that have a significantly higher incidence of HCC. This is consistent with the finding based on the gender-adjusted model shown in Figure 5. For men 61 years of age or younger, a higher level of GP73 (>6.3) is significantly associated with increased HCC incidence (p < 0.001) independent of AFP and AAT levels. The node pair (2,6) represents this sub-group of 49 men. A detailed interpretation of this tree is provided in the text.