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. Author manuscript; available in PMC: 2015 Mar 28.
Published in final edited form as: Annu Rev Clin Psychol. 2014 Jan 15;10:581–606. doi: 10.1146/annurev-clinpsy-032813-153653

Table 1.

Alzheimer’s disease (AD) and frontotemporal dementia (FTD) have distinct neuroanatomical and clinical profiles.

Neurodegenerative
Disease		 Typical Brain
Atrophy		 Primary Cognitive
Symptoms		 Primary Emotional
and Behavioral
Symptoms
AD Medial temporal lobe (entorhinal cortex and hippocampus)
Parietal (precuneus)
Posterior cingulate		 Episodic memory
Language
Visuospatial functioning		 Anxiety
Low mood
Apathy
FTD Frontal lobe (anterior insula, anterior cingulate cortex, orbitofrontal cortex)
Anterior temporal lobe and amygdala		 Executive control Apathy
Disinhibition
Loss of Empathy
Elation