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A simplified diagram of a cell being studied by a patch clamp is shown (80,75). A cell in a physiological bath solution is sealed to a glass pipette that is filled with a solution that makes contact with the electrode (usually a chlorided silver wire). The small currents due to ion movements across the membrane are measured as a voltage drop across a resistor. The glass pipette is coated with a hydrophobic substance to reduce the pipette/bath solution capacitance.
