Figure 3.

Effect of radiation and PF-02341066 on NSCLC xenografts. (A and B) One million cells in 100 μl volume with Matrigel (1:1) were injected subcutaneously into female nude mice. Mice were divided into the following treatment groups: control, PF-02341066 only (50 mg/kg), IR (2 Gy × 5) and IR + PF 02341066. Treatments were initiated when the tumor diameter was 3–5 mm. (C) H460 cells, which are non-responsive to PF-02341066 treatment, were injected into female nude mice without Matrigel and the tumor-bearing animals were divided into 4 groups and treated as described above.