Table 1.

Estimated toxicity for glymes and common organic solvents^a

Solvent	Oral rat LD50 (mg/kg)	Bioaccumulation Factor	Developmental Toxicity	Mutagenicity
Ethanol	(7055b)	1.28	(1.00,c toxicant)	−0.10 (+)
Toluene	1083 (636b)	48.88	0.29 (non)	−0.01 (−)
Benzene	2030 (931b)	30.78	0.29	0.03 (+)
THF	932 (1652b)	2.67	0.48	0.05 (−)
Chloroform	1794 (695b)	5.07 (6.3019)	0.67 (toxicant)	0.45 (−)
Monoglyme	2997	1.66	0.59 (toxicant17)	0.59 (1.00d) (+)e
Diglyme	3779 (5404b)	2.04	0.43 (toxicant17)	0.38
Triglyme	6496	1.73	0.36	0.18 (1.00d) (+)
Tetraglyme	5146 (5140b)	6.97	−0.10	0.23
Pentaglyme	5604	2.85	−0.10	0.33
Hexaglyme	6112	6.02	−0.06	0.26
Ethyl glyme	3949 (3619b)	4.60	0.32 (toxicant17)	0.20
Butyl glyme	4427 (3253b)	24.33	0.47	0.05
Ethyl diglyme	6818 (4968b)	5.82	0.26	0.16
Butyl diglyme	3378 (3901b)	15.57	0.05	0.23

Note:

^aToxicity was estimated with the consensus method using Toxicity Estimation Software Tool (TEST) (http://www.epa.gov/nrmrl/std/qsar/qsar.html); disclaimer: these estimated values are for research and evaluation purposes, not for guiding clinical or production applications;

^bExperimental value from ChemidPlus database (http://chem.sis.nlm.nih.gov/chemidplus/);

^cExperimental value from the CAESAR database (http://www.caesar-project.eu/index.php?page=results&section=endpoint&ne=5);

^dExperimental value from Toxicity Benchmark database (http://doc.ml.tu-berlin.de/toxbenchmark/);

^e‘+’ means mutagenicity positive, ‘−’ means mutagenicity negative.