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. 2013 Nov 8;32(24):3161–3175. doi: 10.1038/emboj.2013.240

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Copyright © 2013, European Molecular Biology Organization

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/.

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I_Kr activation and deactivation properties in mutated and corrected LQT2-hiPSC-derived CMs and in wild-type and mutated hESC-derived CMs. (A, B) Average peak tail current normalized to the maximal current following repolarization to −40 mV in mutated (red) and corrected (black) LQT2-hiPSC-derived CMs (A) and in wild-type (black) and mutated (red) hESC-derived CMs (B). Inset: voltage protocol. (C, D) Average time constants of I_Kr activation (τ) in mutated (red) and corrected (black) LQT2-hiPSC-derived CMs (C) and in wild-type (black) and mutated (red) hESC-derived CMs (D). (E, F) Average slow and fast time constants of I_Kr deactivation (τ_s and τ_f, respectively) in mutated (red) and corrected (black) LQT2-hiPSC-derived CMs (E) and in wild-type (black) and mutated (red) hESC-derived CMs (F).