Figure 7.

AP characteristics in mutated and corrected LQT2-hiPSC-derived CMs and in wild-type and mutated hESC-derived CMs. (A, B) Representative examples of AP measured at 1 Hz (A) and average APD₅₀, APD₉₀, V_max, APA, and MDP (B) in mutated (red) and corrected (black) LQT2-hiPSC-derived CMs. * indicates statistical significance (APD₅₀: P=0.045, APD₉₀: P=0.026; t-test). (C, D) Representative examples of AP measured at 1 Hz (C) and average APD₅₀, APD₉₀, V_max, APA, and MDP (D) in wild-type (black) and mutated (red) hESC-derived CMs. * indicates statistical significance (APD₅₀: P=0.049, t-test).