Figure 5. Host immunity in the genital mucosa.
There is an intense infiltrate of CD4+ (blue) and CD8+ (orange) T-cells and mixed populations of dendritic cells (blue stellate cells), macrophages (purple cells) and NK cells (green cells). This cellular infiltrate produces IFN- γ, TNF-α, RANTES, granzyme B and perforin. B cells and neutralizing antibodies may also be present. The location and function of macrophages, B cells and neutralizing antibodies have not been fully characterized.