Table 1.
Baseline demographic and clinical characteristics of the study population
| Characteristic | Persons who took >12 months to complete treatment (n = 261) n (%) |
Persons who took <12 months to complete treatment (n = 2366) n (%) |
P value* |
|---|---|---|---|
| Age at report date, years, median [IQR] | 44 [31–59] | 45 [30–61] | 1.00 |
| Male sex | 184 (70.5) | 1552 (65.6) | 0.11 |
| Black, non-Hispanic race | 133 (51.0) | 978 (41.3) | 0.004 |
| US-born | 217 (83.1) | 1769 (79) | 0.002 |
| Homeless | 30 (11.5) | 205 (8.7) | 0.14 |
| Correctional facility | 21 (8.0) | 102 (4.3) | 0.01 |
| Long-term care facility | 7 (2.7) | 55 (2.3) | 0.67 |
| HIV infection | 31 (11.9) | 194 (8.2) | 0.04 |
| Alcohol use | 67 (25.7) | 453 (19.1) | 0.01 |
| IDU | 5 (1.9) | 41 (1.7) | 0.80 |
| Non-IDU | 36 (13.8) | 263 (11.1) | 0.22 |
| Extra-pulmonary disease | 73 (28.0) | 510 (21.6) | 0.02 |
| Cavitary disease | 92 (35.2) | 639 (27.0) | 0.006 |
| Smear-positive | 181 (69.3) | 1157 (48.9) | <0.0001 |
| Culture-positive | 225 (86.2) | 1710 (72.3) | <0.0001 |
| Type of treatment | |||
| Exclusively DOT | 154 (59.0) | 1632 (69.0) | 0.001 |
| DOT/SAT combination | 91 (34.5) | 667 (28.2) | 0.03 |
| Exclusively SAT | 10 (3.8) | 46 (1.9) | 0.06 |
| Subsequent TB recurrence | 4 (1.5) | 22 (0.9) | 0.32 |
| Time to completion of treatment, weeks, median [IQR] | 58.7 [53.8–70.0] | 29.8 [26.6–39.6] | <0.0001 |
*
Fisher’s exact and Wilcoxon’s rank sum tests were used to compare categorical and continuous variables, respectively.
IQR = interquartile range; HIV = human immunodeficiency virus; IDU = injection drug use; DOT = directly observed therapy; SAT = self-administered therapy.