Table 7.
Drug intolerance/allergy
| Intolerance/ allergy |
All patients (n = 506) |
Cases: persons who took >12 months to complete treatment (n = 253) |
Controls: persons who took <12 months to complete treatment (n = 253) |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| INH | R | PZA | Any drug | INH | R | PZA | Any drug | INH | R | PZA | Any drug | |
| Fever/chills | 4 | 4 | 2 | 10 | 4 | 2 | 6 | |||||
| Gl upset | 2 | 10 | 9 | 21 | 2 | 2 | 7 | 11 | 2 | 2 | ||
| Pruritus/rash | 8 | 4 | 12 | 6 | 4 | 10 | 2 | 1 | 3 | |||
| Neurologic | 4 | 1 | 5 | 2 | 2 | 2 | 1 | 3 | ||||
| Arthralgias | 5 | 5 | 3 | 3 | 2 | 2 | ||||||
| Flushing | 2 | 2 | 2 | 2 | ||||||||
| Cytopenias | 9 | 9 | 9 | 9 | ||||||||
| Renal failure | 2 | 2 | 1 | 1 | 1 | 1 | ||||||
| Pregnancy | 3 | 3 | 1 | 1 | 2 | 2 | ||||||
| Anaphylaxis | 1 | 3 | 1 | 5 | 1 | 3 | 1 | 5 | ||||
| Any, n (%) | 18 (3.6) | 35 (6.9) | 35 (6.9) | 51 (12.1) | 13 (5.1) | 33 (13.0) | 23 (9.1) | 44 (17.4) | 5 (2.0) | 2 (0.8) | 12 (4.7) | 7 (2.8) |
*
Seven patients were intolerant to both INH and PZA; 5 patients were intolerant to both INH and RMP.
INH = isoniazid; R = rifamycin; PZA = pyrazinamide; GI = gastrointestinal.