Figure 5. Levels of lung immune and inflammatory cells, and Th2 cytokines in hORMDL3zp3-Cre mice.
The number of (A) CD4+, (B) F4/80+, (C) MBP+, and (D) neutrophil elastase+ (NE+) cells per bronchiole of 150–200 μm of internal diameter was quantitated by immunohistochemistry and image analysis in WT and hORMDL3zp3-Cremice at 4, 8, and 26 weeks of age (n=12 mice/group). Levels of IL-13 in (E) BAL and (F) lung, as well as levels of IL-5 in (G) BAL and (H) lung were quantitated by ELISA (n=12 mice/group).