Table 4.
Summary of brain regions showing statistically significant differences
| AD vs. NC (NC vs. AD) | MCI vs. NC (NC vs. MCI) | MCI vs. AD | ||||
|---|---|---|---|---|---|---|
| Measure | Region | Effect size | Region | Effect size | Region | Effect size |
| Fractional anisotropya | Frontal lobes | -0.64(0.70) | Frontal | -0.51 (NS) | Frontal | 0.29 |
| Temporal | -0.74(0.57) | Temporal | -0.46 (0.38) | Temporal | 0.27 | |
| parahippocampal | -0.67 (1.17) | Hippocampus (PHg) | -0.97 (0.97) | PCg | 0.37 | |
| PCg | -0.86(0.84) | PCg | -0.53 (0.65) | Genu | 0.35 | |
| Genu | -0.51(0.63) | Genu | -0.42 (0.41) | Splenium | 0.51 | |
| Splenium | -0.70(1.10) | Splenium | -0.60 (0.44) | |||
| UF | -1.14(1.03) | SLF | -0.77 (NS) | |||
| SLF | -0.85(0.77) | |||||
| Mean diffusivityb diffusivityb | Frontal | 0.50 (-0.75) | Temporal | 0.55 (-0.40) | PCg | -0.40 |
| Temporal | 0.73 (-0.89) | Parietal | 0.86 (-0.69) | Genu | -0.32 | |
| Parietal | 0.72 (-1.03) | Genu | 0.43 (-0.43) | Splenium | -0.04 | |
| Occipital | 0.47 (-0.67) | Splenium | 0.63 (-0.46) | |||
| Hippocampus | 0.60 (-1.17) | PCg | 0.32 (-0.26) | |||
| PCg | 0.69 (-0.74) | Hippocampus | 1.08 (-1.0) | |||
| Genu | 0.50 (-0.67) | |||||
| Splenium | 0.56 (-0.94) | |||||
| UF | 0.66 (-0.72) | |||||
Effect sizes are summarized per region [78,79]. AD, Alzheimer's disease; MCI, mild cognitive impairment; NC, normal controls; PCg, posterior cingulate gyrus; PHg, parahippocampal gyrus; SLF, superior longitudinal fasciculus; UF, uncinate fasciculus. aNegative effect size indicates abnormality and positive effect size indicates integrity of white matter. bPositive effect size indicates abnormality and negative effect size indicates integrity of white matter.