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. 2014 Apr 9;9(4):e93078. doi: 10.1371/journal.pone.0093078

Figure 1. Murine ALAS2 protein schematic indicating mutated amino acid residues.

Figure 1

The green dotted lines represent the relative locations of the three cysteines in the HRMs of ALAS2. C11 and C38 are in the ALAS2 presequence. K313A, R433K, and the heptavariant mutations and their respective positions are indicated according to the amino acid numbering previously described for mature mALAS2 [31], [35], [36]. The amino acid positions according to the numbering for the precursor enzyme are written above the diagram.