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. 2014 Apr 9;9(4):e93078. doi: 10.1371/journal.pone.0093078

Figure 6. Light-induced cell death of HeLa cells expressing mALAS2 variants.

Figure 6

(A) Cell death measured by changes in DNA-bound propidium iodide fluorescence. (B) Cell death measured by changes in DNA-bound DAPI fluorescence. HeLa cells were transfected with expression plasmids for either wild type (WT) or mALAS2 variants and treated with 10 nM paclitaxel 4-hour post-transfection. 48 hours after transfection, cells were stained and analyzed by flow cytometry. Cell death percentage values were compared to that of the pIRES2-ZsGreen1-transfected cells control. Each data set represents three separate experiments ± standard deviation (*p<0.05 and **p<0.01, Student’s t-test).