Table 1. List of PH1-associated mutations tested.

Mutation	Allele	Prior Activity Analysis	Prior Stability Analysis
Group I
L25R	?
G109V	Mi
R111Q	?
G161R	Ma	ma[5], [18]	mi[16]/ma[18]
M195R	Mi
D201E	Ma
L269P	Ma
L284P	Mi
L298P	Mi
L359P	Ma
L384P	Ma
Group II
I56N	Ma Mi
E95K	Mi	mi[11]
G161C	Mi	mi[18], [19], [24]/ma[24]	mi[18], [19]
G161S	Mi	mi[18], [19], [24]/ma[24]	mi[18], [19]
L166P	Mi	mi/ma[24]
M195L	Mi
D243H	?
C253R	Mi	mi/ma[16], [24]
P319L	?	mi[9]/ma[19]	mi[9]/ma[19]
A368T	Mi	mi[9]	mi[9]
Group III
D129H	Ma
L153V	Ma
I279M	?
Q282R	Ma
S287T	?
Group IV
R36C	Mi	mi[16], [24]/ma[24]	mi[16]
G47R	Mi	mi[16]	mi[16]
G82R	Mi	mi[16]	mi[16]
H83R	Mi	mi[9], [11], [16]	mi[9], [16]
W108R	Mi	mi[4],[16],[19]	mi[16], [19]
H261Q	?	mi[16]	mi[16]
E274D	Mi	mi[16]	mi[16]
S275R	Ma Mi	mi[16]	mi[16]