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. 2014 Apr 9;9(4):e94394. doi: 10.1371/journal.pone.0094394

Figure 7. Enriched environment suppressed the upregulation of hippocampal CRH in the rats with postnatal maternal separation.

Figure 7

Enriched environment decreased histone H3 acetylation (A), and increased 5′-cytosine methylation (B) in the Crh, but not Gapdh, promoter region in the hippocampal CA1 in the modeled rats. Enriched environment also significantly suppressed the upregulation of the mRNA (C) and protein expression (D) of CRH in the rats with postnatal maternal separation. N  = 7–8 per group; **, P<0.01.