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. 2014 Apr 9;9(4):e94486. doi: 10.1371/journal.pone.0094486

Figure 3. LDK prevents neuroinflammation and demyelination.

Figure 3

Spinal cord sections obtained on Day 56 from vehicle-treated (A) and LDK-treated (B) SJL/J mice sensitized with PLP139–151 were stained with Luxol fast blue. Infiltration of inflammatory cells in the form of perivascular cuffing (arrowheads) in white matter regions of the spinal cord, meningitis (double arrows) and demyelination (arrows) are indicated. (C) Pathologic scoring of the spinal cord sections was performed as described in the Methods. Data represent the mean pathologic scores+SEM for groups with 7 mice per group. **P<0.005, Student’s paired t-test.