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. 2014 Apr 9;9(4):e94717. doi: 10.1371/journal.pone.0094717

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© 2014 Duyvestyn et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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B6.CD45.1 mice repopulated with bone marrow cells from a c-Cbl^A/− mouse were dosed twice daily with 15 mg/kg of dasatinib for 16 days. WBCs and spleen cells were analyzed by flow cytometry to identify B cell populations that are most sensitive to dasatinib. Shown are representative flow cytometry profiles and data from 3 vehicle and 3 dasatinib treated mice. (A) B220⁺ WBCs and (B) B220⁺ spleen cells were analyzed for the expression of IgM and IgD to identify immature and mature B cells. The gates show immature IgM⁺ IgD⁻ B cells. (C) B220⁺ spleen cells analyzed for the expression of GL7 and CD95 to identify germinal center (GC) B cells. The results are expressed as means ± standard errors. *P<0.05, **P<0.01 using the unpaired Student’s t test.