Table 1. Modeling aspects reviewed in this study.
Aspects | Descriptions |
---|---|
Modeling approach | Dynamic vs. static; aggregate level vs. individual level; deterministic vs. stochastic. |
Assumption on natural immunity | Susceptible-infectious-susceptible (SIS), susceptible-infectious-recovered (SIR) and susceptible-infectious-recovered-susceptible (SIRS)1 |
Model calibration process | Method used for calibration, if any. |
Diseases modeled | HPV-related diseases considered in the model. |
HPV transmission patterns modeled | Heterosexual or homosexual. |
Vaccination and screening strategies assessed | Vaccination strategy (initial vaccination, catch-up vaccination and booster), screening strategy and vaccine coverage rate. |
Input parameters | Vaccine characteristics (efficacy, against infection and/or disease, waning function), transition probabilities, costs, utilities and discount rate. |
1 An SIR model assumes that, after recovery from infection, the individual will not be re-infected (i.e., natural immunity) whereas an SIS model assumes the individual can be re-infected immediately after recovery from infection (i.e., no natural immunity). An SIRS model assumes that natural immunity only exists for a period of time following recovery from infection.