Table 3.

Evaluation of IVF and Participant Characteristics on IVF Failures in Brigham and Women’s Hospital IVF Study, for Mixed and Transitional Models Allowing Varying Effects of Covariates on IVF Outcomes

IVF and Participant Characteristics	Age-failure type interaction		BMI-failure type interaction
	Mixed Model	Transitional Model	Mixed Model	Transitional Model
	OR (95% CI)	OR (95% CI)	OR (95% CI)	OR (95% CI)
Intercepts
Implantation failure	1.00 (referent)	1.00 (referent)	1.00 (referent)	1.00 (referent)
Chemical pregnancy	0.22 (0.17, 0.27)	0.21 (0.17, 0.27)	0.20 (0.16, 0.24)	0.20 (0.16, 0.24)
SAB	0.13 (0.10, 0.18)	0.12 (0.09, 0.17)	0.19 (0.16, 0.24)	0.17 (0.13, 0.22)
Gonadotropin dose	1.26 (1.17, 1.36)	1.20 (1.13, 1.29)	1.25 (1.16, 1.34)	1.20 (1.12, 1.28)
Embryos transferred	0.72 (0.67, 0.78)	0.78 (0.78, 0.83)	0.74 (0.69, 0.79)	0.79 (0.74, 0.84)
Previous livebirth	0.80 (0.68, 0.94)	0.84 (0.73, 0.96)	0.79 (0.67, 0.92)	0.82 (0.72, 0.94)
Down regulation	0.79 (0.67, 0.92)	0.83 (0.72, 0.95)	0.78 (0.67, 0.91)	0.81 (0.71, 0.94)
ICSI	0.99 (0.86, 1.14)	1.01 (0.90, 1.14)	1.02 (0.89, 1.17)	1.03 (0.91, 1.16)
BMI (continuous)	0.99 (0.98, 1.01)	0.99 (0.98, 1.01)	(see Fig S1 in Supplementary Materials)
Age (continuous)	(see Figure 2)		1.09 (1.06, 1.11)	1.07 (1.05, 1.09)
AIC	7652.0	7692.0	7701.0	7738.4

IVF=in vitro fertilization; OR=odds ratio; CI=confidence interval; SAB=spontaneous abortion; ICSI=intracytoplasmic sperm injection; BMI=body mass index; AIC=Akaike’s Information Criterion