TABLE 1.
Patient characteristics among all HIV patients independent of TB status (n=485)
| All patients n=485 (100%) |
No anaemia n=216 (44.5%) |
Mild anaemia n=121 (24.9%) |
Moderate anaemia n=123 (25.4%) |
Severe anaemia n=25 (5.2%) |
p-value | |
|---|---|---|---|---|---|---|
| Patient characteristics | ||||||
| Age, median (IQR) | 33.6 (27.9–40.7) | 34.1 (28.5–41.1) | 33.8 (27.9–40.7) | 33.2 (27.7–41.2) | 29.4 (25.8–33.7) | 0.244 |
| Female (%) | 308 (63.5) | 115 (53.2) | 69 (57.0) | 102 (82.9) | 22 (88.0) | <0.001 |
| Pregnant (%) | 20 (4.1) | 6 (2.8) | 8 (6.7) | 6 (4.9) | 0 | 0.293 |
| BMI, median (IQR) | 23.6 (20.9–27.1) | 23.8 (21.3–28.5) | 23.1 (20.7–26.1) | 23.8 (19.8–26.9) | 21.4 (19.7–24.6) | 0.004 |
| Haemotological testsa | ||||||
| Hemoglobin (g/dL) | 12.0 (10.6–13.4) | 13.5 (12.6–14.4) | 11.7 (11.3–12.2) | 10.0 (9.1–10.6) | 7.5 (7.0–7.7) | <0.001 |
| White blood cell count (cells/μL) | 4.9 (3.9–6.1) | 4.8 (3.9–5.8) | 4.4 (3.6–5.8) | 5.3 (4.1–6.6) | 6.5 (4.9–8.2) | 0.003 |
| Absolute neutrophil count (cells/μL) | 2.6 (1.9–3.6) | 2.6 (1.8–3.5) | 2.3 (1.8–3.1) | 3.0 (2.1–4.0) | 3.7 (2.1–5.7) | <0.001 |
| Absolute lymphocyte count (cells/μL) | 1.6 (1.2–2.1) | 1.6 (1.3–2.0) | 1.5 (1.2–2.0) | 1.5 (1.2–2.1) | 1.4 (0.7–2.2) | 0.343 |
| Platelets (platelets/μL) | 265 (211–335) | 257 (203–319) | 260 (210–328) | 303 (232–382) | 273 (178–414) | 0.002 |
| CD4 cell count (cells/μL)b | ||||||
| Median (IQR) | 169 (96–231) | 192 (126–248) | 157 (86–227) | 143 (60–201) | 129 (35–184) | <0.001 |
| CD4 0–99 | 123 (25.5) | 38 (17.7) | 34 (28.1) | 43 (35.3) | 8 (32.0) | 0.002 |
| CD4 100–199 | 181 (37.5) | 77 (35.8) | 46 (38.0) | 47 (38.5) | 11 (44.0) | |
| CD4 ≥200 | 179 (37.1) | 100 (46.5) | 41 (33.9) | 32 (26.2) | 6 (24.0) | |
| Log viral load (copies/ml), Median (IQR) | 4.6 (4.0–5.0) | 4.4 (3.8–4.8) | 4.6 (4.1–5.0) | 4.8 (4.3–5.3) | 5.2 (4.4–5.6) | <0.001 |
| WHO stage at enrolment | ||||||
| 1 or 2 | 325 (67.0) | 167 (77.3) | 84 (69.4) | 65 (52.9) | 9 (36.0) | <0.001 |
| 3 or 4 | 160 (33.0) | 49 (22.7) | 37 (30.6) | 58 (47.2) | 16 (64.0) | |
| Tuberculosis | 0.920 | |||||
| History of previous TB (%) | 130 (26.8) | 55 (25.5) | 35 (28.9) | 33 (26.8) | 7 (28.0) | |
| Positive WHO symptom screen (%) | 333 (68.7) | 142 (67.0) | 83 (70.9) | 87 (66.4) | 21 (84.0) | 0.312 |
| Prevalence of current culture-confirmed TB (%) | 81 (16.7) | 19 (8.8) | 20 (16.5) | 32 (26.0) | 10 (40.0) | <0.001 |
a
Median (IQR)
b
n=483