Figure 1.

Regression of mean age- and sex-adjusted BMI-SDS and waist-SDS values across the risk-allele scores. The histogram shows that the number of weighted obesity risk alleles was normally distributed in the sample. The black triangles show the mean age- and sex-adjusted BMI-SDS values across the weighted risk-allele scores; the blue diamonds show the mean age- and sex-adjusted waist-SDS values across the weighted risk-allele scores. The solid black line shows the regression line for age- and sex-adjusted BMI-SDS predicted from the polygenic obesity risk score (R², 0.031; beta, 0.177; beta 95% CI, 0.136 to 0.218). The solid blue line shows the regression line for age- and sex-adjusted waist-SDS predicted from the polygenic risk score (R², 0.028; beta, 0.167; beta 95% CI, 0.126 to 0.208).