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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: JAMA Pediatr. 2014 Apr;168(4):338–344. doi: 10.1001/jamapediatrics.2013.4944

Figure 4.

Figure 4

Path diagram showing that Satiety Responsiveness significantly mediates the association between polygenic risk of obesity and waist-SDS. The path diagram shows the simple association between the polygenic obesity risk score (PRS) and Satiety Responsiveness (beta, −0.060; 95% CI, −0.101 to −0.019), the association between the PRS and waist-SDS adjusted for Satiety Responsiveness (beta, 0.153; 95% CI, 0.114 to 0.192), and the association between Satiety Responsiveness and waist-SDS adjusted for the PRS (beta, −0.235; 95% CI, −0.274 to −0.196). The simple association between the PRS and waist-SDS (beta, 0.167; 95% CI, 0.126 to 0.208) was slightly higher than the association between the PRS and waist-SDS adjusted for Satiety Responsiveness (beta Δ 0.016), indicating that Satiety Responsiveness mediated part of the association. The Sobel test confirmed that Satiety Responsiveness significantly mediated the association between the PRS and waist-SDS (P=0.005).