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The effects of metformin (Met) on cell size. Cell size was measured in H9c2 cells 24 hrs after treatment with AngII (200 nM) in the presence or absence of losartan (Los), Met, Nω-nitro-L-arginine methyl ester (L-NAME) and splitomicin (SP) or pifithrin-α (Pf). (A) Representative images of individual cells, (B) cell size (μm), (C) cell size presented as percentage of control. *P < 0.05, **P < 0.01 versus control; +P < 0.05 versus AngII. n = 3–4 per group.
