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The effects of AngII on the level of p53 in cardiomyocytes in the presence or absence of losartan (Los), metformin (Met), Nω-nitro-L-arginine methyl ester (L-NAME) and/or splitomicin (SP). Western blot data were normalized to actin and expressed as fold change relative to control groups. *P < 0.05 versus control; +P < 0.05 versus AngII. n = 10–12 per group.
