Table 1.
Postnatal fluoxetine exposure decreases baseline arachidonic acid incorporation coefficients k* in adult mice.
| Brain Region | Saline (n = 7) | Fluoxetine (n = 12) |
|---|---|---|
| k*, (ml/s/g) × 10−4 | ||
| Telencephalon | ||
| Prefrontal cortex layer I | 7.85 ± 1.13 | 7.44 ± 2.05 |
| Prefrontal cortex layer IV | 8.72 ± 1.12 | 7.84 ± 2.17 |
| Primary olfactory cortex | 8.18 ± 0.99 | 7.21 ± 2.21 |
| Frontal cortex (10) | ||
| Layer I | 8.40 ± 1.37 | 7.30 ± 2.13 |
| Layer IV | 9.27 ± 1.50 | 8.08 ± 2.51 |
| Frontal cortex (8) | ||
| Layer I | 9.03 ± 1.23 | 7.50 ± 2.22 |
| Layer IV | 9.52 ± 1.37 | 8.12 ± 2.32 |
| Pyriform cortex | 7.93 ± 1.05 | 6.41 ± 1.67* |
| Anterior cingulate cortex | 11.48 ± 1.33 | 9.30 ± 1.87** |
| Motor cortex | ||
| Layer I | 8.22 ± 1.36 | 7.17 ± 1.56 |
| Layer II – III | 9.38 ± 1.10 | 7.84 ± 1.97 |
| Layer IV | 11.07 ± 0.70 | 9.10 ± 2.45 |
| Layer V | 10.93 ± 1.04 | 8.80 ± 2.19 |
| Layer VI | 10.22 ± 1.14 | 8.11 ± 1.79** |
| Somatosensory cortex | ||
| Layer I | 8.80 ± 1.49 | 7.30 ± 1.85 |
| Layer II–III | 9.96 ± 1.32 | 8.13 ± 1.97 |
| Layer IV | 11.55 ± 0.95 | 9.72 ± 2.35 |
| Layer V | 11.15 ± 1.06 | 8.88 ± 1.91** |
| Layer VI | 10.29 ± 1.07 | 8.30 ± 1.70** |
| Auditory cortex | ||
| Layer I | 8.14 ± 1.34 | 7.02 ± 2.13 |
| Layer IV | 9.37 ± 1.67 | 8.01 ± 2.41 |
| Layer VI | 8.88 ± 1.64 | 7.03 ± 1.90 |
| Visual cortex | ||
| Layer I | 8.29 ± 1.60 | 6.87 ± 1.94 |
| Layer IV | 9.84 ± 1.28 | 7.75 ± 2.19 |
| Layer VI | 8.93 ± 1.19 | 7.08 ± 2.13 |
| Preoptic area (LPO/MPO) | 8.52 ± 1.04 | 6.74 ± 1.49** |
| Suprachiasmatic nu | 9.37 ± 2.08 | 6.65 ± 1.69*** |
| Globus pallidus | 8.89 ± 0.84 | 7.96 ± 2.09 |
| Bed nu stria terminalis | 8.28 ± 1.04 | 6.65 ± 1.56*** |
| Olfactory tubercle | 7.79 ± 1.45 | 6.99 ± 1.90 |
| Diagonal band Dorsal | 9.70 ± 1.32 | 7.37 ± 1.85*** |
| Ventral | 9.24 ± 0.85 | 7.01 ± 1.88*** |
| Amygdala basolat/med | 6.78 ± 1.69 | 6.16 ± 1.71 |
| Hippocampus CA1 | 6.70 ± 1.73 | 6.19 ± 2.09 |
| CA2 | 7.30 ± 1.75 | 6.59 ± 2.57 |
| CA3 | 7.67 ± 1.63 | 7.01 ± 2.35 |
| Dentate gyrus | 8.55 ± 1.81 | 7.56 ± 2.54 |
| SLM | 11.17 ± 2.63 | 9.61 ± 3.21 |
| Accumbens nucleus | 8.35 ± 1.08 | 7.26 ± 2.08 |
| Caudate putamen | ||
| Dorsal | 9.23 ± 0.77 | 7.27 ± 1.86** |
| Ventral | 9.21 ± 0.99 | 7.46 ± 1.96* |
| Lateral | 9.36 ± 0.80 | 7.66 ± 1.99* |
| Medial | 9.21 ± 0.80 | 7.18 ± 1.76** |
| Septal nucleus lateral | 7.96 ± 0.65 | 6.40 ± 1.57* |
| medial | 9.26 ± 0.95 | 7.54 ± 1.90* |
| Diencephalon | ||
| Habenular nu lateral | 14.35 ± 2.94 | 12.66 ± 4.18 |
| Habenular nu medial | 13.54 ± 2.97 | 12.19 ± 4.45 |
| Lateral geniculate nu dorsal | 12.08 ± 1.78 | 9.38 ± 3.31 |
| Medial geniculate nu | 13.21 ± 2.05 | 9.97 ± 2.66 |
| Thalamus | ||
| Ventroposterior lateral nu | 12.21 ± 2.16 | 9.40 ± 3.44 |
| Ventroposterior medial nu | 11.84 ± 2.13 | 9.08 ± 2.96* |
| Paratenial nu | 11.94 ± 1.05 | 9.92 ± 2.65 |
| Anteroventral nu | 15.26 ± 1.19 | 14.06 ± 3.96 |
| Anteromedial nu | 13.13 ± 1.12 | 10.57 ± 3.02 |
| Reticular nu | 12.91 ± 1.00 | 10.65 ± 2.89 |
| Paraventricular nu | 11.37 ± 1.59 | 9.39 ± 2.52 |
| Parafascicular nu | 11.58 ± 2.15 | 8.82 ± 3.39 |
| Subthalamic nucleus | 11.19 ± 2.00 | 9.42 ± 2.96 |
| Hypothalamus | ||
| Supraoptic nu | 8.54 ± 0.99 | 7.51 ± 1.35 |
| Lateral | 7.99 ± 1.38 | 7.10 ± 1.53 |
| Anterior | 7.85 ± 1.25 | 6.99 ± 1.54 |
| Periventricular | 7.85 ± 1.29 | 7.15 ± 1.40 |
| Arcuate | 8.23 ± 1.75 | 7.22 ± 1.39 |
| Ventromedial | 8.26 ± 1.86 | 7.36 ± 2.08 |
| Posterior | 8.38 ± 2.02 | 6.79 ± 1.64 |
| Mammillary nucleus | 7.54 ± 1.85 | 6.79 ± 1.64 |
| Mesencephalon | ||
| Interpeduncular nucleus | 16.45 ± 2.64 | 13.44 ± 3.59 |
| Substantia nigra | 9.45 ± 0.97 | 7.63 ± 2.24 |
| Pretectal area | 11.51 ± 1.79 | 8.97 ± 2.20* |
| Superior colliculus | 11.23 ± 2.57 | 9.07 ± 1.86 |
| Deep layers | 10.47 ± 1.37 | 8.81 ± 1.79 |
| Inferior colliculus | 19.52 ± 3.54 | 14.52 ± 2.80*** |
| Median Raphe nu | 10.94 ± 3.91 | 9.31 ± 1.44 |
| Dorsal Raphe nu | 10.06 ± 2.47 | 9.24 ± 1.67 |
| Pedunculopontine tegmental nu | 10.64 ± 2.07 | 8.04 ± 1.45*** |
| Rhombencephalon | ||
| Flocculus | 12.89 ± 1.19 | 12.48 ± 2.70 |
| Cerebellar gray matter | 11.73 ± 2.13 | 10.76 ± 2.24 |
| Molecular layer cerebellar gray matter | 12.49 ± 1.99 | 12.17 ± 1.90 |
| Raphe magnus nu | 11.26 ± 3.15 | 8.77 ± 1.37* |
| Raphe pallidus nu | 11.26 ± 2.52 | 8.74 ± 1.55** |
| Locus coeruleus | 12.93 ± 2.84 | 10.96 ± 2.41 |
| Cochlear nu | 13.20 ± 3.97 | 12.05 ± 2.15 |
| Spinal trigeminal nu | 10.31 ± 2.34 | 10.67 ± 1.63 |
| Superior olive | 11.27 ± 2.71 | 9.41 ± 1.57 |
| Medial vestibular nu | 19.29 ± 2.14 | 15.98 ± 2.98* |
| White matter | ||
| Corpus callosum | 6.89 ± 1.13 | 5.48 ± 1.59 |
| Internal Capsule | 5.88 ± 1.44 | 6.15 ± 1.48 |
| Cerebellar white matter | 7.35 ± 0.85 | 6.92 ± 1.34 |
| Non-blood-brain barrier regions | ||
| Subfornical organ | 8.58 ± 0.86 | 7.53 ± 1.53 |
| Median eminence | 7.34 ± 1.84 | 7.28 ± 2.07 |
| Choroid plexus | 25.48 ± 3.08 | 19.62 ± 4.34*** |
Values are mean ± S.D.
Abbreviations: nu, nucleus; lat, lateral; med, medial; SLM, stratum lacunosum-molecule of hippocampus.
Unpaired t-test with P < 0.05*, 0.02**. 0.01***