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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: Prostaglandins Leukot Essent Fatty Acids. 2014 Jan 30;90(5):191–197. doi: 10.1016/j.plefa.2014.01.003

Table 2.

Effects of postnatal fluoxetine exposure on whole-brain enzyme activities and protein levels during adulthood

Saline (n = 10) Fluoxetine (n = 12)
Activity
cPLA2 (pmol/min/mg protein) 5.42 ± 0.41 5.70 ± 0.28
sPLA2 (nmol/min/mg protein) 104.4 ± 7.9 (n = 9) 123.8 ± 11.6
iPLA2 (pmol/min/mg protein) 47.1 ± 4.5 (n = 9) 62.0 ± 2.1**(+31%)
Protein (%, fluoxetine/saline)
iPLA2-VIA 100.0 ± 15.6 (n = 8) 108.3 ± 14.4
COX-1 (69 kDa) 100.0 ± 12.7 105.6 ± 17.6
COX-2 (69 kDa) 100.0 ± 15.9 (n = 8) 102.5 ± 12.3
5-LOX (78 kDa) 100.0 ± 13.5 104.5 ± 9.2
12-LOX (75 kDa) 100.0 ± 12.3 101.9 ± 6.9
15-LOX (79 kDa) 100.0 ± 8.6 93.7 ± 6.9
mPGES (33 kDa) 100.0 ± 10.7 (n = 9) 105.45 ± 6.9
CYP2C9 (59 kDa) 100.0 ± 8.1 79.9 ± 7.1
CYP4A (50-52-54 kDa) 100.0 ± 20.0 25.8 ± 13.3**(−74%)

Values are mean ± SEM.

**

P < 0.01, unpaired t-test