Table 2.
Multivariable β (standard error) parameter estimates^ for modelling viraemia copy-years.
| Factors | Level | No. of Participants [yr=1, yr=5] | MODEL: Baseline
|
MODEL: Time-updated
|
||
|---|---|---|---|---|---|---|
| Estimate (S.E) | p# | Estimate (S.E) | p# | |||
| Age at ART | (per 5 years) | [2073, 1267] | −0.04 (0.01) | <0.01 | −0.03 (0.01) | <0.01 |
|
| ||||||
| Sex | Female | [118, 76] | −0.04 (0.11) | 0.66 | −0.20 (0.08) | 0.02 |
|
| ||||||
| Mode HIV exposure | MSM1 | [1572, 963] | 0.00 | 0.02 | 0.00 | 0.18 |
| Heterosexual | [201, 116] | −0.09 (0.09) | −0.04 (0.07) | |||
| IDU | [107, 64] | 0.21 (0.10) | 0.11 (0.08) | |||
| Other/Blood | [176, 113] | −0.15 (0.08) | −0.07 (0.06) | |||
| Unknown | [17, 11] | 0.27 (0.24) | 0.27 (0.18) | |||
|
| ||||||
| Primary Care Type | GP | [748, 424] | 0.00 | 0.87 | 0.00 | 0.29 |
| Hospital | [586, 391] | −0.01 (0.05) | −0.03 (0.04) | |||
| SHC | [739, 452] | 0.02 (0.05) | −0.06 (0.04) | |||
|
| ||||||
| HBV co-infection | Yes | [89, 56] | −0.01 (0.05) | 0.95 | 0.08 (0.08) | 0.34 |
|
| ||||||
| HCV co-infection | Yes | [223, 144] | 0.16 (0.07) | 0.03 | 0.01 (0.05) | 0.92 |
|
| ||||||
| Prior ARV exposure2 | Yes | [549,432] | 0.46 (0.05) | <0.01 | 0.31 (0.04) | <0.01 |
|
| ||||||
| Initial ART anchor3 | NNRTI | [850, 406] | 0.00 | <0.01 | 0.00 | 0.03 |
| PI | [993, 712] | 0.23 (0.05) | 0.07 (0.04) | |||
| Other | [230, 149] | 0.24 (0.07) | 0.13 (0.06) | |||
|
| ||||||
| CD4 at ART start (cells/μL) | 0 to 200 | [629, 405] | 0.00 | <0.01 | ||
| 201 to 350 | [556, 334] | −0.20 (0.06) | ||||
| 351 to 500 | [430, 256] | −0.16 (0.06) | ||||
| >500 | [458, 272] | 0.01 (0.06) | ||||
|
| ||||||
| pVL at ART start (copies/ml) | 0 to 104 | [927, 533] | 0.00 | <0.01 | 0.00 | <0.01 |
| 104 to 105 | [635, 384] | 0.22 (0.05) | 0.14 (0.04) | |||
| >105 | [511,350] | 0.34 (0.06) | 0.26 (0.04) | |||
|
| ||||||
| Time Updated | ||||||
|
| ||||||
| AIDS illness | Yes | [373, 291] | 0.11 (0.04) | <0.01 | ||
|
| ||||||
| CD4 cell count (cells/μL) | 0 to 200 | [275, 101] | 0.00 | <0.01 | ||
| 201 to 350 | [434, 188] | −0.10 (0.03) | ||||
| 351 to 500 | [510, 273] | −0.18 (0.03) | ||||
| >500 | [854, 705] | −0.30 (0.04) | ||||
|
| ||||||
| Number of ART changes4 | 0 | [1197, 173] | 0.00 | <0.01 | ||
| 1 to 2 | [700, 472] | 0.36 (0.02) | ||||
| 3 to 5 | [159, 392] | 0.57 (0.03) | ||||
| 6 to 10 | [17, 186] | 0.57 (0.04) | ||||
| >10 | [0, 44] | 0.56 (0.07) | ||||
|
| ||||||
| % time ART interruption | 0.0 | [1800, 793] | 0.00 | <0.01 | ||
| 0.1 to 5% | [38, 123] | 0.67 (0.04) | ||||
| 5 to 20% | [65, 168] | 1.10 (0.03) | ||||
| 20 to 50% | [100, 110] | 1.44 (0.04) | ||||
| >50% | [70, 73] | 1.86 (0.05) | ||||
|
| ||||||
| Model Fit Statistics (smaller is better) | ||||||
| AIC | 13773 | 11050 | ||||
| BIC | 13939 | 10982 | ||||
| −LogLikelihood | 6862 | 5491 | <0.01# | |||
^
Linear mixed model, unstructured correlation structure, adjusted for duration of ART and calendar year of ART initiation
#
Analysis of Variance - Likelihood ratio test, alpha=0.05
1
MSM – men who have sex with men.
2
Mono/duo ARV exposure prior to initiating ART.
3
Initial ART regimen was classified as 2 N(t)RTI’s + (NNRTI or PI or Other); N(t)RTI – nucleos(t)ide reverse transcriptase inhibitors; NNRTI – non-nucleoside reverse transcriptase inhibitors; PI – protease inhibitors.
4
Includes any modification to ART regimen.