Under basal conditions, TXNIP prevents SHP2 to interact with VE-cadherin resulting in pY527 Src by CSK. Upon decreased TXNIP expression, SHP2 can be recruited to VE-cadherin, where it dephosphorylates CSK, relieving the inhibitory pY527 and allowing activation of Src via increased pY416. As a consequent of active Src, stress fibers formation is observed.