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. Author manuscript; available in PMC: 2015 Mar 28.
Published in final edited form as: Circ Res. 2014 Feb 10;114(7):1125–1132. doi: 10.1161/CIRCRESAHA.114.301315

Figure 8. Schematic model for TXNIP regulation of Src signaling and stress fiber formation.

Figure 8

Under basal conditions, TXNIP prevents SHP2 to interact with VE-cadherin resulting in pY527 Src by CSK. Upon decreased TXNIP expression, SHP2 can be recruited to VE-cadherin, where it dephosphorylates CSK, relieving the inhibitory pY527 and allowing activation of Src via increased pY416. As a consequent of active Src, stress fibers formation is observed.