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In vivo co-delivery of PTX and siRNA. Oregon green-PTX and siGLO siRNA co-loaded PEG-pp-PEI-PE nanoparticles were injected intravenously in the tumor-bearing mice. At 2h post injection, the dissociated cells from fresh tissues were analyzed by FACS. (A) In vivo cell internalization in organ and tumor cells (histograms); (B) In vivo co-delivery of PTX and siRNA (dot plots). a, Untreated cells; b, PEG-pp-PEI-PE uncleavable/PTX/siRNA; c, PEG-pp-PEI-PE/PTX/siRNA.
