Figure 4.

Inflammation as assessed with the anti-CD-68 (ED-1) marker for microglia/macrophages. There was marked ongoing inflammation (activated microglia/macrophages) in and around the injured cortex (A) and striatum (B) throughout the study period. There were no differences among groups at any time point; however, there was a significant decrease in the density of ED-1+ cells over time. (C) A representative photomicrograph ( × 4) illustrating typical ED-1 staining in lesioned cortex. Values are expressed as mean±s.e.m. ED-1, endothelin-1; EE, enriched environment; ER, enriched rehabilitation; RT, daily reach training; ST, standard housing.