Figure 1.

Representative [¹¹C]ITDM-PET images of the brains of rats without (A) or with (B) unlabeled 4-fluoro-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide (FITM) (1 mg/kg) pretreatment and magnetic resonance imaging (MRI) templates of rat brain (C). Volumes of interest (VOIs) were drawn to generate regional tissue time-activity curves (tTACs) in cerebellum (Ce), pons (Po), hippocampus (Hi), thalamus (Th), cingulate cortex (Ci), and striatum (St). The PET images displayed here reflect the radioactivity summed from 0 to 90 minutes after injection. The color scale represents the standardized uptake value (SUV). [¹¹C]ITDM, N-[4-[6-(isopropylamino)-pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methyl-4-[¹¹C]-methylbenzamide; PET, positron emission tomography.