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letter
. 2014 Feb 5;34(4):585–588. doi: 10.1038/jcbfm.2014.20

Figure 1.

Figure 1

The kinetics of 99mTc-ECD in the brain and the metabolic rate of 99mTc-ECD in mice brain homogenates. (A) The kinetics of 99mTc-ECD in the brain. (B) Typical analytical image of radioactivity on a thin-layer chromatography (TLC) plate in the measurement of metabolic rate (control, 0.243 g/mL; Oat3−/−, 0.237). (C) Time-dependent metabolism of 99mTc-ECD in mice brain homogenates shown in (B) (closed, control; open, Oat3−/−). Regression curves based on first-order kinetics are presented. 99mTc-ECD, 99mTc complex with N,N'-1,2-ethylenediylbis-L-cysteine diethyl ester; Oat3, organic anion transporter 3.