Figure 5.

Uptake of taurocholate (A), a selective organic anion transporting polypeptide (Oatp) substrate, and atorvastatin (B) after hypoxia/reoxygenation (H/R), in hypoxic (Hx) animals, and in normoxic (Nx) controls in the presence and absence of SB431542, a pharmacological transforming growth factor-β (TGF-β)/activin receptor-like kinase 5 (ALK5) inhibitor. Results are expressed as mean±s.d. of six animals per treatment group. Animals were perfused with [³H]taurocholate (1.0 μCi/mL; 10 mmol/L total concentration) or [³H]atorvastatin (0.5 μCi/mL; 0.013 μmol/L total concentration) for 10 minutes. Nx=Normoxia; Hx=Hypoxia. Results are expressed as mean±s.d. of six animals per treatment group. Asterisks represent data points that are significantly different from control.