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. Author manuscript; available in PMC: 2014 Sep 26.
Published in final edited form as: J Med Chem. 2013 Sep 16;56(18):7458–7462. doi: 10.1021/jm400932c

Figure 1.

Figure 1

Top1-mediated DNA cleavage induced by compounds 24, 26, 28, 27, 29, 2 and 18. Lane 1: DNA alone; lane 2: Top1 alone; lane 3: I, 1 RM:; lane 4: Indenoisoquinoline 55, 1 RM; lane 5–25: 24, 26, 28, 27, 29, 2 and 18 at 1, 10 and 100 RM respectively from left to right. Numbers and arrows on the left indicate arbitrary cleavage site positions.