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. Author manuscript; available in PMC: 2014 Sep 26.
Published in final edited form as: J Med Chem. 2013 Sep 16;56(18):7458–7462. doi: 10.1021/jm400932c

Figure 2.

Figure 2

Binding mode of 26 (yellow sticks) at the Top1 (green cartoons) DNA (cyan cartoons) cleavage site. Residues important for ligand binding are highlighted as sticks. H–bonds are dashed black lines.