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. 2014 Mar 26;4(6):660–677. doi: 10.7150/thno.8698

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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In vitro effect of theranostic micelles loaded with iron oxide nanoparticles (A) Hyperthermia study shows that the time-dependent temperature rise of 1 mg/ml of the iron oxide nanoparticles (IOs)-loaded TPGS and F127 micelles on exposure to 89 kA/m alternating current field at 240 kHz frequency. The specific absorption rate value for the IOs-loaded TPGS and F127 micelles was found to be 51.4 and 25.5 Watt/g. (B) The cytotoxic assay performed after hyperthermia treatment of MCF-7 cancer cells incubated with the IOs-loaded TPGS and F127 micelle and Resovist^®. Hyperthermia treatment in all cases leads to significant cell death. Inset image (i) shows the cells incubated with the IOs-loaded TPGS micelles but no AC field applied and inset image (ii) shows the cells incubated with the IOs-loaded TPGS micelles and hyperthermia treatment using AC field. From (ii), it can be seen that after hyperthermia treatment, the cell loses viability and do not attach. Reproduced with permission from Figure 6 of ref. 108 Elsevier Ltd, © (2011).