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. Author manuscript; available in PMC: 2014 Dec 11.
Published in final edited form as: J Am Chem Soc. 2013 Nov 27;135(49):18637–18643. doi: 10.1021/ja409609j

Figure 4.

Figure 4

Comparison of KTQ(E1)dNaM-d5SICS (green) and KTQ(E2)dNaM-d5SICS (blue) with KTQdG with a natural dC-ddG base pair at the post-insertion site (grey). (A) Superposition of duplex portion of primer/template of KTQ(E1)dNaM-d5SICS and KTQ(E2)dNaM-d5SICS with KTQdG. The unnatural base pair in the post-insertion site is shown in ball and stick representation. (B) Superposition of KTQ(E1)dNaM-d5SICS and KTQdG, shown as cartoon. The finger and palm domains which are only slightly affected by the unnatural base pair are transparent. The larger movement of the thumb domain is indicated with black arrows. (C and D) Superposition of unnatural and natural base pair (from KTQdG) at post-insertion site with distance between C1’ atoms indicated in Å, (C) KTQ(E1)dNaM-d5SICS and (D) KTQ(E2)dNaM-d5SICS.