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Secondary structure of DzT in complex with EGFR T790M mRNA and wild-type mRNA. The catalytic core of 10–23 DzT (in blue) is flanked by two binding arms with sequences complimentary to EGFR T790M mRNA (in black). The sequences of wild-type EGFR mRNA (upper panel) and T790M mRNA (lower panel), RY cleavage site (arrow), and mutation site (in red) are indicated. EGFR, epidermal growth factor receptor; mRNA, messenger RNA.
