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. 2014 Mar 4;3(3):e150. doi: 10.1038/mtna.2014.3

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Copyright © 2014 The American Society of Gene & Cell Therapy

Molecular Therapy-Nucleic Acids is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivative Works 3.0 License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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DzT induces apoptosis in an allele-specific manner. (a–d) A549^wt (a), CL1-5^wt (b), H1975^TM/LR (c), and CL97^TM/GA (d) cell numbers were determined at various times after DzT (100 nmol/l) transfection (n = 3). These data are presented as mean ± SD and were analyzed by Student's t-test. Asterisks denote statistical significant differences (P ≤ 0.001). (e, f) DzT induces apoptosis in cells harboring EGFR T790M. H1975^TM/LR and CL97^TM/GA cells were analyzed 72 hours after transfection with DzC or DzT by immunoblotting with the indicated antibodies (e) or flow cytometry stained with AV and PI (f). Counts are presented as percentages. AV, annexin V; PI, propidium iodide.