Figure 2. Apelin reduces perivascular fibrosis.

(A) Representative coronary artery sections stained with Masson’s trichrome. (B) Quantification of the area of perivascular fibrosis was determined as described in materials and methods from a minimum of 15 arteries/mouse, 6–8 mice/group). The data from each experiment is expressed as mean (± S.E.M). *P<0.001 vs saline, †P<0.001 vs apelin, ‡P<0.001 vs Ang II by one-way ANOVA with Bonferroni’s Multiple Comparison Test.