Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The effect of I260Q mutation on binding of ℛ and W dNTP.
| Approach | log(Kd,wt/Kd,mutant)ℛ | log(Kd,wt/Kd,mutant)W | Kd fidelitya |
|---|---|---|---|
| FEP | -1.9±0.8 | 0.0±0.8 | 1.9±1.1 |
|
| |||
| FEP/LIE | -1.8±1.3 | 0.2±1.4 | 2.0±1.9 |
| Experiment | -0.8±0.5 | 0.8±1.7 | 1.6±1.8 |
Kd fidelity = log(Kd,wt/Kd,mutant)W − log(Kd,wt/Kd,mutant)ℛ
