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. Author manuscript; available in PMC: 2014 Apr 10.
Published in final edited form as: Curr Opin Struct Biol. 2012 Sep 19;22(6):733–742. doi: 10.1016/j.sbi.2012.08.004

Fig. 1. Binding of RF1 to the 70S ribosome.

Fig. 1

(a) Positions of RF1 (yellow), P-site tRNA (orange), E-site tRNA (red) and a mRNA (green) bound to the 70S ribosome [23S rRNA (gray), 5S rRNA (light blue), 16S rRNA (cyan), 50S proteins (magenta) and 30S proteins (dark blue)]. (b) The position of A-site tRNA (yellow) in a 70S elongation complex [54] is similar to that of domains 2, 3 and 4 of RF1. (c) Orientation of RF1 in the A site of the 70S ribosome, along with the P-site tRNA (orange). The peptidyl transferase center (PTC), decoding center (DC) and helices h43 (the L11 stalk) and h95 (the sarcin-ricin loop) of 23S rRNA are indicated. (d) The structure of RF1 in its ribosome-bound conformation. The view is rotated approximately 180° from that shown in panels (a) and (c), for clarity. Domains 1, 2, 3 and 4 are shown in green, yellow, blue and magenta, respectively. The conserved GGQ and PVT motifs are shown in red, and the switch loop (see text) is in orange. From ref. [16].

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