Table 1.
Genes related to transformation and carcinogenesis that were altered in NaVO3-transformed clones relative to control clones
| Gene | Full gene name | Fold change |
|---|---|---|
| bcar1 | Breast cancer anti-estrogen resistance 1 | 1.355 |
| brca1 | Breast cancer 1, early onset | −2.082 |
| ccna1 | Cyclin A1 | −2.235 |
| cdh6 | Cadherin 6, type 2, K-cadherin (fetal kidney) | −2.886 |
| cdk7 | Cyclin-dependent kinase 7 | 1.604 |
| cyp1b1 | Cytochrome P450, family 1, subfamily B, polypeptide 1 | 9.194 |
| dner | Delta/notch-like EGF repeat containing | 7.067 |
| dsc2 | Desmocollin 2 | −5.410 |
| dsc3 | Desmocollin 3 | −20.811 |
| e2f5 | E2F transcription factor 5, p130-binding | −2.266 |
| eya4 | Eyes absent homolog 4 (Drosophila) | 18.298 |
| fanca | Fanconi anemia, complementation group A | −1.603 |
| fn1 | Fibronectin 1 | 2.083 |
| gpx7 | Glutathione peroxidase 7 | −3.605 |
| gsta2 | Glutathione S-transferase α 2 | 1.557 |
| hlf | Hepatic leukemia factor | 5.837 |
| itgb3 | Integrin, β 3 (platelet glycoprotein IIIa, antigen CD61) | 1.996 |
| jag1 | Jagged 1 (Alagille syndrome) | 2.197 |
| jarid2 | Jumonji, AT rich interactive domain 2 | 1.619 |
| jun | Jun oncogene | 1.290 |
| kat2a | K (lysine) acetyltransferase 2A | −2.090 |
| kdm5d | Lysine (K)-specific demethylase 5D | 3.108 |
| kiss1 | KiSS-1 metastasis-suppressor | −1.135 |
| lamb1 | Laminin, β 1 | 2.111 |
| nrp1 | Neuropilin 1 | 3.990 |
| pde1c | Phosphodiesterase 1C, calmodulin-dependent 70 kDa | 4.495 |
| plcb4 | Phospholipase C, β 4 | −3.121 |
| prickle1 | Prickle homolog 1 (Drosophila) | 4.390 |
| prkca | Protein kinase C, α | 1.766 |
| rarb | Retinoic acid receptor, β | 7.168 |
| rbp7 | Retinol binding protein 7, cellular | −6.388 |
| rras | Related RAS viral (r-ras) oncogene homolog | 1.379 |
| rxrb | Retinoid X receptor, β | 1.195 |
| satb2 | SATB homeobox 2 | 2.548 |
| serpinb10 | Serpin peptidase inhibitor, clade B (ovalbumin), member 10 | 6.863 |
| set | SET nuclear oncogene | −1.225 |
| skap2 | src kinase associated phosphoprotein 2 | −5.133 |
| snai2 | Snail homolog 2 (Drosophila) | 3.733 |
| srpx2 | Sushi-repeat-containing protein, X-linked 2 | 4.590 |
| stat3 | Signal transducer and activator of transcription 3 | −1.652 |
| stc2 | Stanniocalcin 2 | 2.168 |
| tgfa | Transforming growth factor, α | 3.607 |
| tgfbr2 | Transforming growth factor, β receptor II (70/80 kDa) | 2.331 |
| tsc1 | Tuberous sclerosis 1 | −1.583 |
| txn | Thioredoxin | −1.374 |
| uty | Ubiquitously transcribed tetratricopeptide repeat gene, Y-linked | 10.134 |
| wnt3 | Wingless-type MMTV integration site family, member 3 | −1.369 |
| wnt5a | Wingless-type MMTV integration site family, member 5A | 4.967 |
| wt1 | Wilms tumor 1 | −2.578 |
| xrcc4 | X-ray repair complementing defective repair in Chinese hamster cells 4 | 1.737 |
A subset of 50 genes from DEG.C that was differentially expressed (p-value ≤0.01) in NaVO3-transformed clones relative to control clones from soft agar. These genes may play a role in the early stages of transformation and cancer development, and some of the listed genes are cancer biomarkers. The fold changes reported in this table were generated with GeneSpring GX software.