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. Author manuscript; available in PMC: 2015 Apr 15.
Published in final edited form as: Int J Cardiol. 2014 Feb 20;173(1):1–11. doi: 10.1016/j.ijcard.2014.02.008

Figure 2.

Figure 2

The role of microRNAs in cardiac regeneration. mir15 family suppresses the proliferation of cardiomyocytes and angiogenesis while mir1, -133 and -499 induces fibroblast/adipocyte reprogramming into cardiomyocytes. Mir1 and -499 also promote the conversion of cardiac stem progenitor cells into cardiomyocytes and they can be injected for cardiac regeneration. hPSC or human pleuripotent stem cells can be converted to cardiomyocytes by the induction of mir1, mir133 and mir499.