Table 2.

Incidence rates of overall severe morbidity by CD4% strata during follow-up in the 332 HIV-infected children initiating ART and followed-up at the CePReF between 2004 – 2009. Abidjan. Côte d’Ivoire

			CD4% strata
	Global		< 15% (326.93 CY)			15 – < 25% (247.06 CY)			≥25% (239.17 CY)
	IR*	95%CI	N	IR*	95%CI	N	IR*	95%CI	N	IR*	95%CI
Overall	57.1	[52.1 – 62.5]	265	110.8	[98.3 – 125.0]	108	43.7	[36.2 – 52.3]	91	27.8	[22.7 – 34.2]
WHO Stage 1&2	0.6	[0.3 – 1.4]	1	0.4	[0.1 – 2.3]	2	0.8	[0.3 – 2.9]	2	0.6	[0.2 – 2.2]
WHO Stage 3&4	38.5	[34.5 – 43.0]	182	76.1	[65.8 – 88.0]	71	28.7	[22.8 – 36.3]	60	18.4	[14.3 – 23.6]
Tuberculosis	1.7	[1.0 – 2.9]	11	4.6	[2.6 – 8.2]	2	0.8	[0.3 – 2.9)	1	0.3	[0.1 – 1.7]
Malaria	8.7	[6.9 – 11.0]	29	12.1	[8.5 – 17.4]	21	8.5	[5.6 – 13.0]	21	6.4	[4.2 – 9.8]
Non AIDS defining	6.9	[5.3 – 8.9]	38	15.9	[11.6 – 21.8]	11	4.5	[2.5 – 8.0]	7	2.1	[1.1 – 4.4]
< 5 years
Overall	57.8	[50.8 – 65.8]	93	124.3	[101.5 – 152.3]	81	63.7	[51.3 – 79.2]	57	28.9	[22.3 – 37.4]
WHO Stage 1&2	1	[0.4 – 2.6]	1	1.3	[0.3 – 7.5]	2	1.6	[0.5 – 5.7]	1	0.5	[0.1 – 2.8]
WHO Stage 3&4	36.8	[31.3 – 43.2]	62	82.9	[64.7 – 106.2]	52	40.9	[31.2 – 53.6]	33	16.7	[11.9 – 23.4]
Tuberculosis	2,0	[1.0 – 3.9]	6	8,0	[3.8 – 17.5]	2	1.6	[0.5 – 5.7]	0	-	-
Malaria	12,0	[9.1 – 15.9]	13	17.4	[10.2 – 29.7]	17	13.4	[8.4 – 21.4]	18	9.1	[5.8 – 14.4]
Non AIDS defining	5.3	[3.5 – 8.0]	9	12,0	[6.4 – 22.8]	7	5.5	[2.7 – 11.3]	5	2.5	[1.1 – 5.9]
≥ 5 years
Overall	56.4	[49.6 – 64.1]	172	104.6	[90.2 – 121.5]	27	22.5	[15.5 – 32.8]	34	26.3	[18.9 – 36.8]
WHO Stage 1&2	0.3	[0.1 –1.4]	0	-	-	0	-	-	1	0.8	[0.2 – 4.3]
WHO Stage 3&4	40.6	[34.9 – 47.3]	121	73.6	[61.7 – 87.8]	19	15.9	[10.2 – 24.8]	28	21.7	[15.0 – 31.3]
Tuberculosis	1.5	[0.7 – 3.2]	5	3,0	[1.3 – 7.1]	0	-	-	1	0.8	[0.2 – 4.3]
Malaria	5.6	[3.7 – 8.4]	16	9.7	[6.0 – 15.8]	4	3.3	[1.4 –8.5]	3	2.3	[0.8 – 6.8]
Non AIDS defining	8.5	[6.1 – 11.8]	29	17.7	[12.3 – 25.3]	4	3.3	[1.4 – 8.5]	2	1.6	[0.5 – 5.6]

^*IR: Incidence rate