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. Author manuscript; available in PMC: 2014 Apr 10.
Published in final edited form as: Nat Struct Mol Biol. 2013 Oct 6;20(11):1325–1332. doi: 10.1038/nsmb.2678

Figure 5.

Figure 5

miR-106 family regulation of TGF-β pathway components TGFBR2 and DAB2. (a) Association between miR-106 family members and predicted target genes TGFBR2 and DAB2 across cancer types. Cancer types are color coded as in Figure 1, and REC scores are listed for each pair. (b) The relationship between miR-106b expression and TGFBR2 and DAB2 mRNA expression in tumor and representative normal samples in four different cancer types. (c) Endometrioid tumors have a recurrent focal genomic amplification spanning the mir-106b locus. Copy-number alterations in the region for 18 samples with focal amplification of the mir-106b locus. Samples are sorted by copy-number amplification level. (d) Expression of miR-106b in endometrioid tumors with diploid mir-106b and tumors with focal mir-106b amplification. (e) Expression of miR-106b and TGFBR2 in endometrioid tumors; tumor samples with focal mir-106b amplification are highlighted, and expression in normal samples is included for comparison.