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. 2013 Dec 15;8(2):323–336. doi: 10.1016/j.molonc.2013.12.005

Figure 4.

Figure 4

PU‐H71 delays initiation of tumors in the A673 xenograft model in NSG mice. A, mice injected s.q. with A673 cells expressing GFP luciferase were randomized to control, early treatment and late treatment groups and were imaged weekly. B, total flux of tumors was measured from week 2 to week 5 for control, early treatment and late treatment groups. C, The weights of tumors in the three groups at week 5. Significance is shown by p‐value <0.05 (*), <0.005 (**) and <0.0005 (***). D, Representative images of immunohistochemical staining of control and PU‐H71 treated mice tumors for CD31. Mean number of microvessels that stained positive for CD31 were counted at 200× in control and PU‐H71 treated mice tumors. E, immunoblot analysis of AKT, pAKT, EWS‐FLI1 and β actin proteins in cell lysates from tumors extracted from control mice and PU‐H71 treated mice.