Table 3.
Genotype and allele distributions of TNFRI and TNFRII gene polymorphisms from healthy individuals from Novosibirsk (South-Western Siberia, Russia, n = 150).
| Gene | SNP | Genotype and allele | % | n | P a |
|---|---|---|---|---|---|
| TNFRI | −609 G/T, rs4149570 | GG | 30.9 | 46 | 0.405 |
| GT | 52.3 | 78 | |||
| TT | 16.8 | 25 | |||
| G | 57 | ||||
| T | 43 | ||||
|
| |||||
| TNFRI | −1207 G/C, rs4149569 | GG | 34.7 | 52 | 0.942 |
| GC | 48.7 | 73 | |||
| CC | 16.7 | 25 | |||
| G | 59 | ||||
| C | 41 | ||||
|
| |||||
| TNFRII | −1709 A/T, rs652625 | AA | 90.7 | 136 | 0.548 |
| AT | 9.3 | 14 | |||
| TT | — | — | |||
| A | 95 | ||||
| T | 5 | ||||
|
| |||||
| TNFRII | −3609 C/T, rs590368 | CC | 35.3 | 53 | 0.45 |
| CT | 50.7 | 76 | |||
| TT | 14 | 21 | |||
| C | 61 | ||||
| T | 39 | ||||
a P value for Hardy-Weinberg equilibrium. SNP: single nucleotide polymorphism; TNFR: tumor necrosis factor receptor; GT: Guanidine/Thymine; GC: Guanidine/Cytosine; AT: Adenine/Thymine; CT: Cytosine/Thymine.